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Against the terrifying backdrop of a biological apocalypse, a Native teenager, Brian, comes out to his older sister, Faith, and homophobic brother, Charles. Conflict erupts among them as desperate survivors from the city seek refuge on the rez from the horrors of a 'megapox' epidemic that is quickly devastating urban populations across North America. Through a perilous journey to the city for food, where they rescue Brian's 'friend' in the process (an outrageous drag queen named Tonya), the hungry and frightened youth reach acceptance by facing down their fears.